Chev Chelios (Jason Statham), has survived the fall from a helicopter that occurred at the end of the first movie. Immediately after his fall, he is abducted off the ground by a group of Chinese medics, who take to farm his organs. However, Chev wakes up mid-surgery and sees them take out his heart and replace it with a mechanical one. He then wakes up and kills the operators, but must chase after his heart which has been stolen. He then runs into his old girlfriend Eve Lydon (Amy Smart) who believed him to be dead.